A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Eukaryotic DNA replication is initiated at multiple origins through a tightly regulated sequence of events: origin licensing, helicase activation and assembly of the replisome. The replicative ...

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the ...