A preclinical study has reported that simultaneous inhibition of cyclin-dependent kinases 2 and 4/6 produced durable tumour ...

Cyclin D1 is one of the drivers of the cell cycle, and its deregulation may promote the development of tumours. Surprisingly, this protein also mediates the repair of damaged DNA, a mechanism that ...

This study was carried out by Prof. Qiang Liu (Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University). In the study, researchers found that the palbociclib-resistant breast cancer ...

A protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research. Cyclin D1, a protein that helps push a ...

Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply ...

Incidental lymphoma during sentinel lymph node biopsy for breast cancer. Background: To evaluate the cyclin D1 expression in breast cancer patients and to investigate its correlation with other ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

Circle Pharma, a leader in macrocycle drug discovery and development, announced the submission of its first Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) ...

Proxygen GmbH has disclosed molecular glue degraders comprising a cullin-ring E3 ligase (CRL) binding moiety acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degradation inducers. They are ...

The research, focused on the role of cyclin, one of the most important protein molecules needed for cell division. It describes the identification of three different types of cyclin in the parasite, ...