The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

Entering the fourth year of Covid-19, vaccination has become the frontline of protective measures to control the disease, as global nations have all but given up on mass mitigation strategies such as ...

A Japanese research team has uncovered how sugar chains (glycans) modifications dynamically regulate the structure and function of human immunoglobulin G (IgG) antibodies. By integrating nuclear ...

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...

Researchers analyzing 761 first-trimester pregnancies found that SARS-CoV-2 was rarely detected in placental tissues, ...