In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

As a cell divides, its DNA -the genetic material- is duplicated and condensed into structures called chromosomes, which are carefully organized and distributed so that each daughter cell acquires a ...

The protein complex responsible for the distribution of chromosomes during cell division is assembled in the transition regions between heterochromatin and euchromatin. The centromere is a specialized ...

The kinetochore attaches the centromeric region of chromosomes to spindle microtubules, allowing equatorial chromosome segregation during mitosis. Proteomic analyses suggest that the kinetochore is a ...

The kinetochore connects chromosomes to spindle microtubules, corrects attachment errors, and triggers the separation of sister chromatids. It is built from more than 100 proteins, grouped into around ...

Scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is vital to proper DNA ...

This is a preview. Log in through your library . Abstract Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 15 (Apr. 12, 2005), pp. 5408-5413 (6 pages) The budding yeast kinetochore is comprised of >60 proteins ...

Cell division builds our bodies, supplying all cells in our tissues and organs, from the skin to the intestine, from the blood to the brain. It not only allows these organs to grow, but also to ...

Robert Blackwell, Oliver Sweezy-Schindler, Christopher Edelmaier, Zachary R. Gergely, Patrick J. Flynn, Salvador Montes, Ammon Crapo, Alireza Doostan, J. Richard ...