Researchers at University Medical Center Utrecht have uncovered a previously underappreciated mechanism that helps immune cells to respond rapidly to infections. Using advanced long-read RNA ...

Focusing on this aspect, we present the RMaP challenge, where RNA modification methods can be jointly tested, evaluated, and compared using selected metrics with the purpose of evaluating both the ...

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare ...

A new single-cell technology is giving scientists their clearest view yet of immune cell behavior—capturing not just genetic intent, but real-time activity. By measuring RNA and proteins ...

Nanopore direct RNA sequencing (dRNA-seq) is a powerful tool for transcriptomics 1. Unlike other RNA sequencing methods, dRNA-seq does not require the conversion of RNA to cDNA. It therefore allows ...

National Cancer Institute researchers have developed a method called HORNET for characterizing 3D topological structures of large and flexible RNA molecules. Scientists used atomic force microscopy ...

An interdisciplinary team of Rice University researchers has uncovered previously unknown relationships between bacteriophages—viruses that infect bacteria—and their bacterial hosts, offering a ...

While bulk sequencing quickly became the preferred method, scRNA-seq has increased in popularity over the last decade. In 2015, just 6 % of RNA-seq papers used single-cell methodologies. By 2025, the ...

Morgan Hiebert (left) studies drug-resistant tuberculosis within the National Reference Centre for Mycobacteriology (Winnipeg, Manitoba) led by Hafid Soualhine, situated in the National Microbiology ...

Understand the stages of a standard RNA-seq bioinformatics workflow, including the role of QC, alignment, gene expression quantification, and specialized application analyses Identify key QC metrics ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

SINGAPORE – Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method, called ‘sm-PORE-cupine’, to study individual RNA molecules and reveal how their structures ...