lupus.bmj

DIA proteomics of FFPE renal biopsies reveals two molecular subtypes of lupus nephritis and identifies APOL1 as candidate biomarker for stratification

Introduction Lupus nephritis (LN) exhibits substantial clinical and pathological heterogeneity. We aimed to define proteomics-based molecular subtypes of LN and identify candidate biomarkers for ...
Science

SKI is critical to counter TGF-β signaling to promote T cell function and autoimmunity

Transforming growth factor–β (TGF-β) is central to suppressing T cell function to maintain tolerance and immune homeostasis.

Experimental drug shows promise in reversing high blood pressure's toll on kidneys and heart in mice

High blood pressure affects nearly 1 in 8 people worldwide, and its impact goes far beyond a number on a blood pressure monitor. It can quietly damage the heart, kidneys and brain, making it one of ...
TMCnet

MemoHoney Update 2026 Introduces a Ten-Ingredient Supplement Format as Part of Its Portfolio Expansion

New York City, NY, Aug. 14, 2026 (GLOBE NEWSWIRE) -- MemoHoney has introduced a dietary supplement formulated around ten ...
BioSpace

Novartis Fabhalta® (iptacopan) receives FDA traditional approval as first and only complement inhibitor to significantly slow kidney function decline in primary IgAN

Basel, July 17, 2026 – Novartis today announced that the US Food and Drug Administration (FDA) has granted traditional approval for Fabhalta ® (iptacopan) to slow kidney function decline in adults ...
verywellhealth

6 Types of Treatment for Complement 3 Glomerulopathy

Managing complement 3 glomerulopathy involves several treatment options aimed at slowing disease progression and protecting kidney function. These may include blood pressure control, steroids, ...
Healthline

What Is C3 Glomerulopathy (C3G) and Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)?

C3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare kidney conditions caused by an overactive complement system, part of the immune system. C3G ...
WebMD

What Is Complement 3 Glomerulopathy?

Also called C3G, this rare kidney disease often affects children and young adults, but it can happen at any age. It has a major impact on a person’s health and life. C3G has two forms: dense deposit ...
C&EN

Activation of the ‘complement system’ helps trigger dangerous sickle-cell-disease outcome

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...
Healio

‘Important discovery’ shows how complement cascade drives systemic inflammation

Please provide your email address to receive an email when new articles are posted on . A protein known as granzyme K was recently shown to be a driver of inflammation by activating the complement ...
PNAS

Complement C3d enables cell-mediated immunity capable of distinguishing spontaneously transformed from nontransformed cells

Tumors are immunogenic in part because of somatic mutations that originate novel peptides that once presented on MHC engage cell-mediated immunity (CMI). However, in spite of the higher mutation load ...