Overall, these in vitro experiments demonstrate that pharmacological activation of TRPML1 stimulates AMPK via a Ca 2+ -CaMKKβ-dependent pathway, thereby promoting GLUT4 translocation to the PM. This ...

Humans make thousands of decisions under ambiguity every day, where most times the probabilities of getting beneficial outcomes are not fully known. Although ambiguity aversion is well characterized ...

Foveal attentional processing coordinates with peripheral attention to dynamically shape global attention allocation and fixation behavior during active vision.

CRISPR/Cas9-induced DNA double-strand breaks (DSBs) are widely used for genome engineering, yet their capacity to provoke sister chromatid exchange (SCE) and associated genome instability remains ...

This Review delineates postmenopausal age-related lobular involution (ARLI) in the breast that remains only partially resolved. In contrast to the conventional view of persistent lobules as passive ...

Argunşah et al. investigate the mechanisms underlying the differential response dynamics of barrel vs septa domains in shaping the responses to single vs multiple whiskers. Based on the observation of ...

Drosophila walking program in a physical model of the fly body, demonstrating that achieving plausible output dynamics does not in and of itself imply biologically meaningful simulation. Evidence for ...

This important study on multisensory learning examines the effect of integrating color vision and olfaction in the center for learning and memory (the mushroom body) in the fruit fly brain, and finds ...

However, the strength of evidence is incomplete because the principal conclusions rely on post hoc responder analyses and methodological ambiguities that weaken the support for the claimed causal ...

This important study demonstrates that nutrient resorption efficiency in the widespread wetland grass Phragmites australis is largely canalized by phylogeographic lineage, ecotype and geographic ...

This is a valuable study addressing a debated question in brain repair research by testing whether NeuroD1 can convert brain immune cells into nerve cells using a virus-free genetic approach and live ...

This valuable study provides key insights into the role of the G protein-coupled receptor GPR34 in an Alzheimer's disease (AD) model. Notably, its findings differ, at least in part, from those of ...