4Gamers on Instagram: "如果你喜歡《絕命精神病院實驗》合作逃脫遊戲，但又覺得該遊戲玩起來太恐怖，海外團隊 Two Horn Unicorn 開發的《S.E.M.I. – Side Effects May Include...》畫風就可愛多了，同樣是逃脫遊戲，卻又有不一樣的挑戰與樂趣。 《S.E.M.I.》是一款 4 人合作生存逃脫遊戲，從角色都穿著束縛服就知道，玩家所扮演的都是相當嚴重的精神病患，而遊戲的目的便是透過單人一己之力或最多 4 人合作，想辦法逃離這所奇妙的實驗病院。 在《S.E.M.I.》遊戲中，玩家扮演的精神病患需要在各個不同的房間解謎，尋找打開房門的方法，而某些房間還會有警衛把守，因此也可能上演互毆的戲碼。 而玩家亦可以在不同的實驗設施取得不同的藥劑，進而獲得不同異能，例如發射雷射光，或是身體變大或變小。 不過，遊戲最大的特色（也是限制）便是每位玩家都有 San 值，不論是跑步、跳躍還是戰鬥都會累積發瘋值，一旦發瘋不僅無法操控角色，身上的能力也會隨著失控為場面更添混亂。 有趣的是，根據官方資訊，這遊戲所有的逃脫關卡似乎都是實驗病院的一環，玩家成功逃
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